Bethanien lies on the C14 Pad, which turns off the B4, approx 110 kilometer west of Keetmanshoop and then goes to the north.
The village has a strong spring and as early as 1804 - Orlam Nama settled in this area. In 1814, the missionary Johann Hinrich Schmelen was sent to Bethanien by the London Mission Society to try convert the Nama. Schmelen built the first stonehouse in Namibia, now known as the "Schmelen House". It is a National Monument and houses a mission history museum of Bethanien.